vrijdag 24 mei 2013
Melissa, Mentha, Prunella und Herpes labiales
Antivirale Phyto-Wirkstoffe zur topischen Behandlung von banalen, rezidivierenden Lippenherpes-Episoden Jürgen Reichling1, Paul Schnitzler2
1Institut für Pharmazie und Molekulare Biotechnologie, Abteilung Biologie, Universität Heidelberg
2Department für Infektiologie, Virologie, Universität Heidelberg
Phyto-antiviral agents for the topic treatment of recurrent herpes labialis episodes
During in-vitro studies, essential oils of various origins and alcoholic extracts of plants of the mint family (Lamiaceae) have proven extraordinarily effective against herpes simplex virus type 1 (HSV-1). Using the plaque reduction test, the investigated plant products could be shown to inactivate cell-free virions and thus reduce or erase their infectiosity. Cell-free HSV virions mainly occur during the blistering phase. The highly infectious secretion of the blisters is an important source of infection for susceptible humans, especially seronegative babies and children. In our experimental studies, alcoholic extracts of self-heal (Prunella vulgaris), lemon balm (Melissa officinalis) and peppermint (Mentha x piperita) exhibited a dual mechanism by inactivating cell-free virions and also by reducing the infection of cells pretreated with these extracts by more than 80 %. This latter finding indicates that these extracts can effectively block virus attachment to host cells. Interestingly, the essential oils as well as the Lamiaceae extracts were also able to decisively reduce the infectivity of acyclovir-resistant herpesviruses, probably due to the fact that acyclovir and the plant drugs inhibit the viral replication cycle of HSV-1 in different locations. Preliminary clinical studies indicate that patients with recurring herpes labialis episodes may benefit from the topic treatment with essential oils and lemon balm extracts.